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Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
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Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
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Related Experiment Video

Updated: Jun 23, 2026

Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres
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Chitosan-Based Self-Healing Hydrogel: From Fabrication to Biomedical Application.

Siyu Pan1, Chongyu Zhu2, Yuwei Wu3

  • 1The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.

Polymers
|September 28, 2023
PubMed
Summary

Chitosan-based self-healing hydrogels offer biocompatible solutions for medicine. These smart materials show promise in tissue regeneration, drug delivery, and biosensors.

Keywords:
chitosancustomized drug deliveryfabricationhydrogelself-healingsmart biosensorsthree/four dimensional (3D/4D) printingtissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Biocompatible self-healing hydrogels are advanced soft materials with significant biomedical potential.
  • Chitosan-based hydrogels, utilizing dynamic imine bonds, are notable for their mild synthesis, biocompatibility, and physiological self-recovery.
  • These materials are gaining attention for various biomedical applications.

Purpose of the Study:

  • To provide a comprehensive review of chitosan-based self-healing hydrogels.
  • To summarize their design, fabrication, and diverse biomedical applications.
  • To discuss future challenges and perspectives in this field.

Main Methods:

  • Review of existing literature on chitosan-based self-healing hydrogels.
  • Analysis of fabrication techniques, focusing on dynamic imine bond chemistry.
  • Synthesis of information on applications in tissue regeneration, drug delivery, biosensors, and 3D/4D printing.

Main Results:

  • Chitosan-based self-healing hydrogels can be prepared under mild conditions with excellent biocompatibility.
  • These hydrogels exhibit efficient self-healing capabilities in physiological environments.
  • Key applications include tissue engineering scaffolds, controlled drug release systems, sensitive biosensors, and advanced 3D/4D printing.

Conclusions:

  • Chitosan-based self-healing hydrogels represent a promising class of biomaterials.
  • Their unique properties facilitate diverse biomedical applications, from regenerative medicine to smart devices.
  • Further research is needed to overcome current challenges and unlock their full potential.