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Semiautomated Longitudinal Microcomputed Tomography-based Quantitative Structural Analysis of a Nude Rat Osteoporosis-related Vertebral Fracture Model
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Osteoporosis and risk of fracture in heart transplant patients

Marine Forien1, Romain Coralli1, Constance Verdonk2

  • 1Rheumatology Department, Départements Médico-Universitaires (DMU) Locomotion, Bichat Hospital Assistance Publiques des Hopitaux de Paris (APHP), Paris, France.

Frontiers in Endocrinology
|September 28, 2023
PubMed

Insights

Heart transplant recipients face a high risk of bone fractures, particularly vertebral fractures, within the first year post-transplant. This study highlights the prevalence and risk factors for these fragility fractures.

Area of Science:

  • Cardiology
  • Orthopedics
  • Endocrinology

Background:

  • Heart transplantation is associated with significant bone loss, increasing fracture risk.
  • Fractures commonly occur within the first year after heart transplantation.
  • Understanding fracture prevalence and risk factors is crucial for patient management.

Purpose of the Study:

  • To evaluate the prevalence of fragility fractures in heart transplant patients.
  • To identify independent risk factors associated with fractures in this population.

Main Methods:

  • Prospective, monocentric study including patients within 10 years post-heart transplantation.
  • Bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry (DXA).
  • Radiographies used to detect vertebral fractures.

Main Results:

  • 27% of 79 heart transplant patients experienced incident fractures post-transplant.
  • Vertebral fractures were most common; 28% had osteoporosis.
  • Lower BMD at the femoral neck and total hip was significantly associated with fractures.

Conclusions:

  • Heart transplant patients have a high risk of vertebral fractures.
  • The first year after heart transplantation is a critical period for fracture risk.
  • BMD is a key indicator for fracture risk in these patients.
Abstract

Keywords:
bone mineral densityfracturesheart transplantosteoporosisvertebral fracture (VF)

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