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Updated: Jul 15, 2025
10:28
Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
Published on: September 20, 2018
6.5K
A New Epigenetic Crosstalk: Chemical Modification Information Flow
Hongwoo Lee1, Young-Joon Park1,2, Pil Joon Seo1,3
1Department of Chemistry Seoul National University Seoul 08826 Republic of Korea.
Advanced Genetics (Hoboken, N.J.)
|September 28, 2023
Summary
Chemical modifications in DNA, RNA, and proteins are relayed during gene expression. This study explores the crosstalk between chromatin and RNA modifications, proposing a framework for information transmission.
Area of Science:
- Molecular Biology
- Epigenetics
- Biochemistry
Background:
- The central dogma describes genetic information flow from DNA to protein.
- Gene expression involves not only sequential information but also chemical modifications of DNA, RNA, and proteins.
- Understanding the interplay of these modifications is crucial for deciphering gene regulation.
Purpose of the Study:
- To present recent evidence on the bidirectional interplay between chromatin and RNA modifications.
- To explore how RNA modifications influence protein chemical modifications.
- To propose a framework for the transmission of chemical modification information across DNA, RNA, and protein.
Main Methods:
- Review of recent scientific literature and evidence.
- Analysis of co-transcriptional and co-translational modification relays.
- Development of a hypothetical framework based on existing data.
Main Results:
- Evidence supports a bidirectional relationship between chromatin and RNA modifications.
- Certain RNA modifications appear to impact protein chemical modifications.
- Crosstalk among DNA, RNA, and protein modifications occurs during transcription and translation.
Conclusions:
- Chemical modifications are actively relayed during gene expression, extending beyond the central dogma.
- A dynamic crosstalk exists between chromatin, RNA, and protein modifications.
- The proposed framework highlights the transmission of chemical modification information in molecular biology.
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