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Bidirectional crosstalk between the peripheral nervous system and lymphoid tissues/organs
Angela Boahen1, Dailun Hu2, Murray J Adams3
1Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Seri-Kembangan, Selangor, Malaysia.
Frontiers in Immunology
|September 28, 2023
Summary
The peripheral nervous system (PNS) directly communicates with the immune system. Disruptions in this neuroimmune axis can lead to disease, highlighting potential therapeutic targets.
Area of Science:
- Neuroimmunology
- Physiology
- Pathology
Background:
- The central nervous system (CNS) broadly influences immunity via systemic factors.
- The peripheral nervous system (PNS) exhibits specific, localized interactions with immune components.
- Imbalances within the PNS are implicated in disease pathogenesis.
Purpose of the Study:
- To review the hardwiring and crosstalk between the PNS and immune system.
- To explore neuroimmune connections in health and disease.
- To understand the bidirectional communication between nervous and immune systems.
Main Methods:
- Review of existing literature on neuroimmune interactions.
- Analysis of anatomical and physiological connections between PNS and immune tissues.
- Exploration of in vitro and in vivo studies.
Main Results:
- Neuroimmune cell units form the basis for bidirectional communication.
- The PNS modulates immune responses in peripheral and lymphoid tissues.
- Understanding these interactions is key to deciphering disease mechanisms.
Conclusions:
- Neuroimmune interactions are critical for immune system regulation.
- Targeting these pathways offers therapeutic potential for various disorders.
- Further research into neuroimmune modulation could yield novel treatments.
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