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Updated: Jul 15, 2025

Comprehensive Evaluation of the Effectiveness and Safety of Placenta-Targeted Drug Delivery Using Three Complementary Methods
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Update on hydroxychloroquine use in pregnancy

Wassan Nori1, Nabeeha Najatee Akram2, Raid M Al-Ani3

  • 1Department of Obstetrics and Gynecology, Mustansiriyah University, Baghdad 10052, Iraq. dr.wassan76@uomustansiriyah.edu.iq.

World Journal of Experimental Medicine
|September 28, 2023
PubMed

It is well-known that hydroxychloroquine (HCQ) treats malaria, systemic lupus erythematosus, and rheumatoid arthritis in women for its immunomodulatory and anti-inflammatory action. Additionally, HCQ was used in cases with refractory antiphospholipid syndrome. HCQ safety was reinforced in pregnant women owing to insignificant reports of adverse pregnancy outcomes and major congenital malformation. Recently, HCQ was tested in cases with chronic placental inflammation with a promising result of increased life birth; however, its benefit needs further validation. We aimed to highlight the recent updates for HCQ use in various conditions in pregnancy.

Keywords:
Antiphospholipid syndromeCOVID-19Chronic placental inflammationHydroxychloroquinePreeclampsiaPregnancy

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