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Lisa Amalie Gottlieb1, Jacob Mosgaard Larsen2, Dominik Linz1

  • 1Biomedicinsk Institut, Københavns Universitet.

Ugeskrift for Laeger
|September 28, 2023
PubMed
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Atrial fibrillation (AF), a common heart rhythm disorder, significantly impacts quality of life and survival. This review explores AF causes, common co-existing conditions, and personalized treatment strategies.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology

Background:

  • Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, severely affecting patient quality of life.
  • AF is associated with increased risks of heart failure, ischemic stroke, and mortality.
  • The underlying mechanisms of AF are intricate, involving multiple pathophysiological pathways.

Purpose of the Study:

  • To review the complex etiology of atrial fibrillation.
  • To identify and discuss the most frequent comorbidities associated with AF.
  • To explore potential individualized treatment options for patients with AF.

Main Methods:

  • Literature review of atrial fibrillation.
  • Analysis of pathophysiological pathways in AF.
  • Examination of comorbidities and their role in AF pathogenesis.

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Main Results:

  • AF etiology is multifactorial, involving complex pathophysiological processes.
  • Common comorbidities significantly contribute to AF development and progression.
  • Individualized treatment approaches are crucial for managing AF.

Conclusions:

  • Understanding AF pathogenesis and comorbidities is key for effective management.
  • Personalized treatment strategies can improve outcomes for AF patients.
  • Further research into AF etiology and treatment is warranted.