A CASE OF EPSTEIN-BARR VIRUS-ASSOCIATED PRIMARY VITREORETINAL LYMPHOMA IN AN IMMUNOSUPPRESSED PATIENT
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Published on: March 30, 2018
Chunxiao Sun1, Yuki Muraoka, Kenji Ishihara
1Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto City, Kyoto, Japan.
Purpose:
To describe a rare case of Epstein-Barr virus (EBV)-positive primary vitreoretinal lymphoma in an immunosuppressed patient.
Methods:
Observational case report.
Results:
A 64-year-old man under immunosuppressive therapy for rheumatic arthritis was referred for 2 months of blurred vision and decreased visual acuity in the right eye. Only mutton-fat keratic precipitates and mild vitreous opacity were found in the right eye without (sub)retinal or sub-retinal pigment epithelial lesions. Vitreous biopsy and systemic workup suggested the diagnosis of primary vitreoretinal lymphoma of diffuse large B-cell lymphoma subform. Neoplastic cells stained positive for EBV antigens, EBV-encoded small RNA, and Epstein-Barr nuclear antigen 2, consistent with EBV-positive diffuse large B-cell lymphoma. Intravitreal methotrexate was effective in improving ocular symptoms.
Conclusion:
The case provided evidence on the association of EBV infection with primary vitreoretinal lymphoma.
