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Published on: May 4, 2021
Asprosin, a novel glucogenic adipokine implicated in type 2 diabetes mellitus
Hongcui Diao1, Xue Li2, Yeqiu Xu3
1Department of Endocrinology, Jinan Central Hospital, Shandong University, Jinan, China.
Abstract:
Asprosin, encoded by penultimate two exons (exon 65 and exon 66) of the gene Fibrillin 1 (FBN1), has been recently discovered to be a novel hormone secreted by white adipose tissues during fasting. The glucose metabolism disorders are often accompanied by increased asprosin level. Previous research suggests that asprosin may contribute to the development of diabetes by regulating glucose homeostasis, appetite, insulin secretion, and insulin sensitivity. In this review, we summarize the recent findings from studies on asprosin and its association with Type 2 diabetes mellitus, and discusses its mechanisms from various aspects, so as to provide clinical diagnosis and treatment ideas for T2DM.
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