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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
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Polyphyllins in cancer therapy: A systematic review and meta-analysis of animal studies

Yan Bai1, Mengmeng Li1, Dongjie Geng1

  • 1Zhejiang Provincial Key Laboratory of Resources Protection and Innovation of Traditional Chinese Medicine, Hangzhou 311300, China; College of Food and Health, Department of Traditional Chinese Medicine, Zhejiang Agriculture & Forestry University, Hangzhou 311300, China; State Key Laboratory of Subtropical Silviculture, Zhejiang Agriculture and Forestry University, Hangzhou 311300, China.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|September 28, 2023
PubMed
Abstract

Insights

Polyphyllins demonstrate significant anticancer effects by reducing tumor volume and weight in animal models. Further research is needed due to study heterogeneity, but findings suggest therapeutic potential for these natural compounds.

Area of Science:

  • Pharmacology
  • Natural Products
  • Oncology

Background:

  • Polyphyllins are natural compounds with known antitumor properties.
  • Clinical application of polyphyllins is limited by a lack of clinical trials.
  • This study investigates the efficacy of polyphyllins in preclinical cancer models.

Approach:

  • A systematic review and meta-analysis was conducted.
  • Multiple electronic databases were searched to identify relevant studies.
  • Risk of bias was assessed, and meta-analysis was performed using RevMan and Stata software.

Key Points:

  • Polyphyllins significantly reduced tumor volume (SMD: -3.35; p < 0.00001) and tumor weight (SMD: -3.79; p < 0.00001) in animal models.
  • No significant impact on animal weight was observed, indicating a favorable safety profile within tested doses.
  • Antitumor mechanisms involve modulation of P53, NF-kB, AMPK, and ERK signaling pathways.

Conclusions:

  • Polyphyllins exhibit significant anticancer activity at experimental doses.
  • Heterogeneity in study results necessitates further investigation.
  • Polyphyllins show promise as a potential cancer therapeutic agent.
Keywords:
Cancer therapyMeta-analysisPolyphyllin

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