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Relapsing polychondritis: focus on cardiac involvement
Ruxue Yin1, Mengzhu Zhao1, Dong Xu1
1Key Laboratory of Rheumatology and Clinical Immunology, Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Science, Ministry of Education, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Science & Technology, Beijing, China.
Frontiers in Immunology
|September 29, 2023
Summary
Cardiac involvement in relapsing polychondritis (RP) is linked to age, central nervous system (CNS) issues, high neutrophil-to-lymphocyte ratio (NLR), and longer disease duration. This heart involvement is mutually exclusive with airway issues in RP patients.
Area of Science:
- Rheumatology
- Cardiology
- Internal Medicine
Background:
- Relapsing polychondritis (RP) can lead to severe cardiac events and poor prognosis.
- Understanding the clinical characteristics of RP with cardiac involvement is crucial for patient management.
Purpose of the Study:
- To analyze the clinical characteristics of relapsing polychondritis patients who have cardiac involvement.
- To identify risk factors and patterns associated with cardiac involvement in RP.
Main Methods:
- Retrospective analysis of hospitalized RP patients from December 2005 to December 2021.
- Univariate and multivariate logistic regression analyses were employed to identify risk factors.
Main Results:
- Cardiac involvement was present in 24.1% of inpatients with RP.
- Independent risk factors for cardiac involvement included older age, central nervous system (CNS) involvement, neutrophil-to-lymphocyte ratio (NLR) > 6.41, and disease duration > 4 years.
- Cardiac involvement was mutually exclusive with tracheobronchial and chest wall involvement, forming distinct clinical patterns.
Conclusions:
- Cardiac involvement in RP is significantly associated with age, CNS involvement, NLR, and disease duration.
- The presence of cardiac involvement in RP is inversely related to airway involvement.
- Routine cardiac monitoring with echocardiography and electrocardiography is recommended for RP patients.
Keywords:
cardiaccentral nervous systemneutrophil-to-lymphocyte ratioprognosisrelapsing polychondritisrisk factorMore Related Videos
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