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Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...

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Related Experiment Video

Updated: Jul 15, 2025

Two-way Valorization of Blast Furnace Slag: Synthesis of Precipitated Calcium Carbonate and Zeolitic Heavy Metal Adsorbent

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Quaternium-18 and Quaternium-18 Bentonite.

Priya Cherian¹, Wilma F Bergfeld², Donald V Belsito²

¹Cosmetic Ingredient Review Senior Scientific Analyst/Writer.

International Journal of Toxicology

|September 29, 2023

Summary

The Expert Panel for Cosmetic Ingredient Safety confirmed Quaternium-18 and Quaternium-18 Bentonite are safe for cosmetic use. This conclusion is based on newly available studies and updated product information.

Keywords:

Cosmetics Quaternium-18 Quaternium-18 Bentonite Safety

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Area of Science:

Cosmetic Science
Dermatology
Toxicology

Background:

The safety of Quaternium-18 and Quaternium-18 Bentonite was previously assessed in 1982.
Updated scientific literature and product usage data have become available since the original assessment.

Purpose of the Study:

To re-evaluate the safety of Quaternium-18 and Quaternium-18 Bentonite as cosmetic ingredients.
To consider newly available scientific studies and updated information on product types and concentrations.

Main Methods:

Review of newly available scientific studies.
Analysis of updated information on cosmetic product types.
Assessment of current concentrations of use for cosmetic ingredients.

Main Results:

Newly available studies were reviewed by the Expert Panel for Cosmetic Ingredient Safety.
Updated information regarding product types and concentrations of use was considered.

Conclusions:

Quaternium-18 and Quaternium-18 Bentonite are confirmed safe for cosmetic ingredient use.
Safety is affirmed within the described practices of use and concentration levels.