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Computed Tomography Cardiac Angiography Before Invasive Coronary Angiography in Patients With Previous Bypass
Daniel A Jones1,2,3,4, Anne-Marie Beirne1,3,4, Matthew Kelham1,3,4
1Centre for Cardiovascular Medicine and Devices (D.A.J., A.-M.B., M.K., K.S.R., M.A., L.W., N.F., R.R., A.B., A.A., A.M.), Barts Heart Centre, Barts Health NHS Trust, London, UK.
Insights
Computed tomography cardiac angiography (CTCA) before invasive coronary angiography (ICA) significantly reduces procedure time, contrast-induced nephropathy, and complications in patients with prior coronary artery bypass grafting.
Area of Science:
- Cardiology
- Radiology
- Interventional Cardiology
Background:
- Coronary artery bypass grafting (CABG) patients often require invasive coronary angiography (ICA).
- ICA in these patients is technically challenging with higher complication risks.
- Previous studies suggest computed tomography cardiac angiography (CTCA) may aid ICA, but lacked randomized trial data.
Purpose of the Study:
- To assess the benefit of adjunctive CTCA prior to ICA in patients with previous CABG.
- To evaluate CTCA's impact on procedural duration, patient satisfaction, and contrast-induced nephropathy.
- To analyze secondary outcomes including procedural complications and major adverse cardiac events.
Main Methods:
- Single-center, open-label randomized controlled trial (RCT).
- 688 patients randomized 1:1 to CTCA+ICA or ICA alone.
- Co-primary endpoints: ICA duration, patient satisfaction, contrast-induced nephropathy. Secondary endpoints: complications, major adverse cardiac events.
Main Results:
- CTCA+ICA group had significantly shorter ICA duration (18.6 vs. 39.5 min).
- Improved patient satisfaction and reduced contrast-induced nephropathy (3.4% vs. 27.9%) in CTCA+ICA group.
- Lower procedural complications (2.3% vs. 10.8%) and 1-year MACE (16.0% vs. 29.4%) with CTCA+ICA.
Conclusions:
- Pre-procedural CTCA significantly improves ICA outcomes in CABG patients.
- CTCA reduces procedure time, contrast-induced nephropathy, and complications.
- CTCA should be considered for patients with prior CABG undergoing ICA.
Background:
Patients with previous coronary artery bypass grafting often require invasive coronary angiography (ICA). However, for these patients, the procedure is technically more challenging and has a higher risk of complications. Observational studies suggest that computed tomography cardiac angiography (CTCA) may facilitate ICA in this group, but this has not been tested in a randomized controlled trial.
Methods:
This study was a single-center, open-label randomized controlled trial assessing the benefit of adjunctive CTCA in patients with previous coronary artery bypass grafting referred for ICA. Patients were randomized 1:1 to undergo CTCA before ICA or ICA alone. The co-primary end points were procedural duration of the ICA (defined as the interval between local anesthesia administration for obtaining vascular access and removal of the last catheter), patient satisfaction after ICA using a validated questionnaire, and the incidence of contrast-induced nephropathy. Linear regression was used for procedural duration and patient satisfaction score; contrast-induced nephropathy was analyzed using logistic regression. We applied the Bonferroni correction, with P<0.017 considered significant and 98.33% CIs presented. Secondary end points included incidence of procedural complications and 1-year major adverse cardiac events.
Results:
Over 3 years, 688 patients were randomized with a median follow-up of 1.0 years. The mean age was 69.8±10.4 years, 108 (15.7%) were women, 402 (58.4%) were White, and there was a high burden of comorbidity (85.3% hypertension and 53.8% diabetes). The median time from coronary artery bypass grafting to angiography was 12.0 years, and there were a median of 3 (interquartile range, 2 to 3) grafts per participant. Procedure duration of the ICA was significantly shorter in the CTCA+ICA group (CTCA+ICA, 18.6±9.5 minutes versus ICA alone, 39.5±16.9 minutes [98.33% CI, -23.5 to -18.4]; P<0.001), alongside improved mean ICA satisfaction scores (1=very good to 5=very poor; -1.1 difference [98.33% CI, -1.2 to -0.9]; P<0.001), and reduced incidence of contrast-induced nephropathy (3.4% versus 27.9%; odds ratio, 0.09 [98.33% CI, 0.04-0.2]; P<0.001). Procedural complications (2.3% versus 10.8%; odds ratio, 0.2 [95% CI, 0.1-0.4]; P<0.001) and 1-year major adverse cardiac events (16.0% versus 29.4%; hazard ratio, 0.4 [95% CI, 0.3-0.6]; P<0.001) were also lower in the CTCA+ICA group.
Conclusions:
For patients with previous coronary artery bypass grafting, CTCA before ICA leads to reductions in procedure time and contrast-induced nephropathy, with improved patient satisfaction. CTCA before ICA should be considered in this group of patients.
Registration:
URL: https://www.
Clinicaltrials:
gov; Unique identifier: NCT03736018.
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