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Related Concept Videos

EDTA: Auxiliary Complexing Reagents01:26

EDTA: Auxiliary Complexing Reagents

614
EDTA titrations are usually carried out in highly basic conditions, where the fully deprotonated form of EDTA, Y4−, actively complexes with the free metal ions in the solution. Several metal ions precipitate as hydrous oxide (hydroxides, oxides, or oxyhydroxides) under these conditions, lowering the concentration of free metal ions in the solution. For this reason, auxiliary complexing agents or ligands such as ammonia, tartrate, citrate, or triethanolamine are used in EDTA titrations to...
614
EDTA: Indirect and Alkalimetric Titration01:23

EDTA: Indirect and Alkalimetric Titration

963
Unlike direct titration, back-titration, and displacement titration, indirect titration is an EDTA titration method for quantifying anions. In the indirect titration method, anions are precipitated as their insoluble salts with excess metal ions. The filtrate containing the excess metal ions is directly titrated with standard EDTA until the endpoint is achieved. Another approach involves extracting the metal ion and back-titrating with standard EDTA to obtain the endpoint. In this way, the...
963
EDTA: Chemistry and Properties01:22

EDTA: Chemistry and Properties

2.0K
Polydentate ligands are most widely used in complexometric titrations because they form more stable complexes with the metal ions than mono- or bidentate ligands due to the chelate effect. Examples of polydentate ligands are ethylenediaminetetraacetic acid (EDTA), crown ethers, and cryptands. The most important feature of optimal polydentate ligands is the ability to form 1:1 complexes in a single-step process. Amino carboxylic acid derivatives are frequently used as complexing agents. EDTA is...
2.0K
EDTA: Direct, Back-, and Displacement Titration01:30

EDTA: Direct, Back-, and Displacement Titration

2.9K
The EDTA titration types for metal ion analysis include direct titration, back-titration, and replacement titration.
Direct titration involves buffering the metal ion solution to the desired pH and directly titrating with standard EDTA until the endpoint. The optimum pH ensures a large conditional formation constant of metal−EDTA and visibility of the free indicator color in the solution. In addition, auxiliary complexing reagents are used to prevent the precipitation of metal hydroxides...
2.9K
Masking and Demasking Agents01:19

Masking and Demasking Agents

2.5K
EDTA titrations may necessitate masking and demasking agents to temporarily protect a particular metal ion in a mixture from the EDTA reaction. These agents facilitate the sequential analysis of the metal ions by forming stable complexes with some—but not all—metal ions during certain steps.
There are many masking agents, such as cyanide, fluoride, triethanolamine, thiourea, and 2,3-bis(sulfanyl)propan-1-ol (formerly 2,3-dimercapto-1-propanol), with the masking agent chosen based on...
2.5K
Effects of EDTA on End-Point Detection Methods01:18

Effects of EDTA on End-Point Detection Methods

297
Different methods, such as visual observance of metal-ion indicators, spectroscopic techniques, and potentiometric methods, can determine the endpoint of an EDTA titration.
In the visual method, metal-ion indicators (metallochromic dyes), which have distinct colors in their free and complex forms, are added to the mixture to signal the titration's end point. They form stable complexes with metal ions, but these complexes are weaker than the corresponding metal–EDTA complexes. As a...
297

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Related Experiment Video

Updated: Jul 15, 2025

Collection and Analysis of Arabidopsis Phloem Exudates Using the EDTA-facilitated Method
09:38

Collection and Analysis of Arabidopsis Phloem Exudates Using the EDTA-facilitated Method

Published on: October 23, 2013

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EDTA and Salts.

Priya Cherian1, Wilma F Bergfeld1, Donald V Belsito1

  • 1Cosmetic Ingredient Review Senior Scientific Analyst/Writer.

International Journal of Toxicology
|September 29, 2023
PubMed
Summary
This summary is machine-generated.

The Expert Panel for Cosmetic Ingredient Safety confirmed that EDTA and certain salts are safe for cosmetic use. This conclusion is based on newly available studies and updated information on product types and concentrations.

Keywords:
Calcium Disodium EDTADiammonium EDTADipotassium EDTAEDTAHEDTATEA-EDTATetrasodium EDTATripotassium EDTATrisodium EDTATrisodium HEDTAsafety, cosmetics

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Area of Science:

  • Cosmetic Science
  • Toxicology
  • Dermatology

Background:

  • The safety of cosmetic ingredients is crucial for consumer health.
  • Previous safety assessments for EDTA and certain salts were conducted in 1998.
  • Updated data on product formulations and usage levels are essential for re-evaluation.

Purpose of the Study:

  • To review newly available scientific studies on EDTA and certain salts.
  • To assess updated information on product types and concentrations of use for these ingredients.
  • To confirm the safety of EDTA and certain salts as cosmetic ingredients based on current data.

Main Methods:

  • Systematic review of newly available scientific literature.
  • Analysis of updated data on cosmetic product types.
  • Evaluation of current concentrations of use for EDTA and certain salts.

Main Results:

  • Newly available studies were reviewed since the 1998 assessment.
  • Updated information on product types and concentrations of use was considered.
  • EDTA and certain salts were found to be safe in current cosmetic applications.

Conclusions:

  • EDTA and certain salts are confirmed as safe cosmetic ingredients.
  • Safety is assured within the specified practices of use and concentration.
  • The Expert Panel's findings support the continued use of these ingredients in cosmetics.