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Related Experiment Videos

Acetaldehyde syndrome after celiac plexus alcohol block.

J Noda, S Umeda, K Mori

    Anesthesia and Analgesia
    |December 1, 1986
    PubMed
    Summary

    Facial flushing during celiac plexus alcohol blocks may indicate acetaldehyde syndrome. Patients lacking aldehyde dehydrogenase I (ALDH I) showed higher acetaldehyde levels and flushing, suggesting a link to genetic factors.

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    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Genetics

    Background:

    • Celiac plexus alcohol block can cause adverse reactions like facial flushing, palpitations, and hypotension.
    • These symptoms are often attributed to ethanol levels, but an alternative hypothesis suggests acetaldehyde syndrome.

    Purpose of the Study:

    • To investigate the hypothesis that facial flushing during celiac plexus alcohol block is due to acetaldehyde syndrome.
    • To correlate patient phenotypes of aldehyde dehydrogenase (ALDH) with the occurrence of flushing and blood acetaldehyde levels.

    Main Methods:

    • Five patients undergoing celiac plexus alcohol block had blood ethanol and acetaldehyde levels measured pre- and post-procedure (6 hours).
    • Aldehyde dehydrogenase (ALDH) phenotypes were determined from hair roots.

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  • Patients' history of facial flushing after ethanol ingestion was recorded.

    • Main Results:

    • Patients experiencing "flushers" exclusively lacked the ALDH I phenotype.
    • Flushers exhibited significantly higher blood acetaldehyde levels within 10 minutes post-block compared to non-flushers.
    • A history of facial flushing after consuming small amounts of ethanol predicted the likelihood of acetaldehyde syndrome.

    Conclusions:

    • Facial flushing during celiac plexus alcohol block is likely acetaldehyde syndrome, not solely due to ethanol.
    • ALDH I deficiency is strongly associated with increased acetaldehyde levels and flushing.
    • Pre-procedure assessment of ethanol sensitivity can help anticipate and manage potential acetaldehyde syndrome.