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Reverse cardio-oncology: A budding concept.
Chhabi Satpathy1, Trinath Kumar Mishra1, Subhasish Singh1
1Department of Cardiology, MKCG Medical College and Hospital, Berhampur, Odisha, India.
Indian Heart Journal
|September 29, 2023
Summary
Cardio-oncology now explores reverse cardio-oncology, investigating cancer risk in heart disease patients. Shared mechanisms like inflammation and factors like obesity link cardiovascular disease and cancer.
Area of Science:
- Cardio-oncology
- Oncology
- Cardiovascular Medicine
Background:
- Cardio-oncology traditionally focuses on cancer treatment's cardiac side effects.
- Emerging research highlights bidirectional links between cancer and cardiovascular disease (CVD).
- Reverse cardio-oncology investigates increased cancer risk in individuals with pre-existing CVD.
Purpose of the Study:
- To review the novel concept of reverse cardio-oncology.
- To discuss the magnitude, mechanisms, and classification of this emerging field.
- To understand the interplay between CVD and cancer development.
Main Methods:
- Literature review of current research in cardio-oncology and related fields.
- Analysis of common pathophysiological pathways linking cancer and heart failure (HF).
- Examination of shared risk factors such as obesity and diabetes.
Main Results:
- Identified shared mechanisms including chronic inflammation and clonal hematopoiesis.
- Highlighted common risk factors like obesity and diabetes contributing to both conditions.
- Established the foundation for understanding cancer risk in CVD patients.
Conclusions:
- Reverse cardio-oncology represents a significant new frontier in understanding cancer and CVD.
- Shared underlying mechanisms and risk factors underscore the connection between these diseases.
- Further research is crucial to define the scope and clinical implications of reverse cardio-oncology.
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