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Abnormalities in modular connectivity of functional brain networks and cognitive changes in patients with anti

Dongying Huang1, Caitiao Lv1, Zexiang Chen1

  • 1Department of Neurology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Brain Research
|September 29, 2023
PubMed
Abstract

Insights

Patients with anti-NMDAR encephalitis (ANMDARE) show altered brain functional networks, with enhanced connectivity within certain brain modules. These changes in brain connectivity may underlie cognitive deficits in ANMDARE.

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Systems Biology

Background:

  • Anti-NMDAR encephalitis (ANMDARE) is an autoimmune disorder associated with significant cognitive and psychiatric symptoms.
  • Understanding the neural underpinnings of cognitive dysfunction in ANMDARE is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the alterations in brain functional networks in patients with ANMDARE.
  • To explore the relationship between intramodule and intermodule brain connectivity and cognitive function in ANMDARE.

Main Methods:

  • Resting-state functional MRI (rs-fMRI) data from 30 ANMDARE patients and 30 healthy controls (HCs) were analyzed.
  • Brain functional matrices were constructed to assess functional connectivity (FC) within and between modules.
  • Whole-brain functional topology and participation coefficients (PC) were calculated.

Main Results:

  • ANMDARE patients exhibited enhanced intramodular FC in occipito-parietal-temporal and parahippocampal regions compared to HCs.
  • Significant differences in intermodular connectivity, indicated by altered participation coefficients, were observed in specific brain regions.
  • No significant differences in global topological properties or correlations with cognitive/emotional scales were found.

Conclusions:

  • ANMDARE is characterized by enhanced intramodular functional connectivity and altered intermodular brain network organization.
  • These findings provide a global network perspective on the pathophysiological mechanisms underlying cognitive changes in ANMDARE.
Keywords:
Anti-N-methyl-D-aspartate receptor encephalitisFunctional connectionGraph theoryModularity

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