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Natural products as a source of new anticancer chemotypes

Francesco Melfi1, Simone Carradori1, Noemi Mencarelli1

  • 1Department of Pharmacy, "G. d'Annunzio" University of Chieti-Pescara, Chieti, Italy.

Expert Opinion on Therapeutic Patents
|September 30, 2023
PubMed
Abstract

Insights

Natural compounds offer promising cancer therapies. This review explores their anticancer mechanisms, chemical optimization, and patentability, focusing on recent advancements and legislation.

Area of Science:

  • Natural product chemistry
  • Cancer therapeutics
  • Drug discovery

Background:

  • Natural products are a vital source for novel cancer treatments.
  • Cancer therapy faces challenges like chemoresistance and relapse.
  • Targeted interventions and adjuvant strategies are crucial.

Purpose of the Study:

  • To review recent advances in natural compounds for cancer therapy.
  • To analyze anticancer mechanisms and chemical optimization of natural products.
  • To discuss the patentability of natural compounds in the US and Europe.

Main Methods:

  • Literature review of anticancer natural compounds.
  • PRISMA-guided patent search (2019 onwards).
  • Inclusion of relevant scientific publications.

Main Results:

  • Comprehensive analysis of recent natural compound anticancer mechanisms.
  • Discussion of chemical optimization strategies.
  • Overview of patentability legislation for natural compounds.

Conclusions:

  • Natural compounds remain a promising area for cancer drug discovery.
  • Understanding mechanisms and optimization is key for therapeutic development.
  • Patentability considerations are important for commercialization.
Keywords:
Canceralkaloidschalconesflavonoidslignansphytocannabinoidsstilbenesterpenes

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