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Anastasia L Gant Kanegusuku1, Clarence W Chan1, Peter H O'Donnell2,3

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|September 30, 2023
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Summary

Pharmacogenomics (PGx) implementation has advanced, but pre-prescription consultations are not standard. This review details strategies and resources for developing PGx programs, especially in academic settings, and discusses overcoming implementation challenges.

Keywords:
Pharmacogenomicsclinical guidelineimplementationprecision medicine

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Area of Science:

  • Pharmacogenomics
  • Clinical Implementation
  • Academic Medicine

Background:

  • Significant progress has been made in reducing barriers to clinical pharmacogenomics (PGx) over the last decade.
  • Despite advancements, pharmacogenomic consultation before prescribing therapeutics remains uncommon in mainstream clinical practice.

Purpose of the Study:

  • To review the current landscape of PGx implementation.
  • To focus on strategies for implementing PGx programs within academic institutions, using The University of Chicago as a case study.
  • To provide an updated guide to resources that support the development of PGx programs.

Main Methods:

  • Literature review and analysis of implementation strategies.
  • Case study examination of PGx implementation at an academic institution.
  • Compilation of resources for PGx program development.

Main Results:

  • Identified key strategies for integrating PGx into academic clinical settings.
  • Highlighted available resources to aid in the establishment and expansion of PGx services.
  • Discussed persistent challenges and innovative solutions for widespread PGx adoption.

Conclusions:

  • Academic institutions play a crucial role in advancing clinical pharmacogenomics.
  • Overcoming implementation barriers requires strategic planning, resource utilization, and addressing ongoing challenges.
  • Continued efforts are needed to make PGx consultation a routine part of therapeutic prescribing.