Elevated high-sensitivity C-reactive protein levels increase the risk of new-onset cardiac conduction disorders
Lili Wu1,2, Meimei Wu3, Dandan Zhao2
1Department of Cardiology, Shanghai Songjiang District Central Hospital, Shanghai, China.
Insights
Elevated high-sensitivity C-reactive protein (hsCRP) levels significantly increase the risk of cardiac conduction disorders, including atrioventricular block and bundle branch blocks. Higher hsCRP indicates a greater risk, suggesting a potential target for prevention strategies.
Area of Science:
- Cardiology
- Inflammation Research
- Public Health
Background:
- Inflammatory responses are linked to cardiovascular diseases.
- The association between inflammation and cardiac conduction disorders is not well-established.
- Community-based cohort studies are crucial for understanding disease risk factors.
Purpose of the Study:
- To investigate the impact of inflammatory responses on the risk of developing cardiac conduction disorders.
- To determine if elevated high-sensitivity C-reactive protein (hsCRP) is a risk factor for conduction abnormalities.
- To explore the dose-dependent relationship between hsCRP levels and conduction disorder risk.
Main Methods:
- A community-based cohort study involving 86,234 participants.
- Classification of participants into hsCRP ≤ 3 mg/L and hsCRP > 3 mg/L groups.
- Multivariate Cox proportional hazard models and restricted cubic spline functions were employed to analyze associations.
Main Results:
- Higher hsCRP levels (hsCRP > 3 mg/L) were associated with increased risks of atrioventricular block, left bundle branch block, and right bundle branch block.
- A linear, dose-dependent relationship was observed between hsCRP levels and the risk of cardiac conduction disorders.
- Every 1 SD increase in log (hsCRP) correlated with a higher risk of these disorders.
Conclusions:
- High hsCRP levels are an independent risk factor for cardiac conduction disorders.
- hsCRP levels demonstrate a dose-dependent association with the risk of conduction disorders.
- These findings may inform new strategies for the prevention of cardiac conduction disorders.
Background:
Previous studies have reported that inflammatory responses can promote the onset of cardiovascular diseases; however, its association with cardiac conduction disorders remains unclear. The present community-based cohort study aimed to elucidate the effects of inflammatory responses on the risk of developing cardiac conduction disorders.
Methods:
After the exclusion of participants failing to meet the inclusion criteria, 86,234 eligible participants (mean age: 50.57 ± 11.88 years) were included. The participants were divided into high-sensitivity C-reactive protein (hsCRP) ≤ 3 mg/L, and hsCRP > 3 mg/L groups based on hsCRP values. Multivariate Cox proportional hazard model was used to analyze the relationship between inflammatory responses and various cardiac conduction disorders.
Results:
After adjusting for confounding factors, we observed that compared with the hsCRP ≤ 3 mg/L group, the hsCRP > 3 mg/L group exhibited increased risks of atrioventricular block (hazard ratio [HR]:1.64, 95%confidence interval [CI] 1.44-1.87) and left (HR:1.25, 95% CI 1.07-1.45) and right bundle branch block (HR:1.31, 95% CI 1.17-1.47). Moreover, the risk of various cardiac conduction disorders increased for every 1 standard deviation increase in log (hsCRP). The restricted cubic spline function confirmed a linear relationship between log (hsCRP) and the risk of developing cardiac conduction disorders (All nonlinearity P > 0.05).
Conclusions:
High hsCRP levels are an independent risk factor for cardiac conduction disorders, and hsCRP levels are dose-dependently associated with the risk of conduction disorders. Our study results may provide new strategies for preventing cardiac conduction disorders.
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