Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thoracic Aorta01:15

Thoracic Aorta

1.8K
The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...
1.8K
The Thoracic Cage: Sternum01:17

The Thoracic Cage: Sternum

6.3K
The thoracic or rib cage forms the body's thorax (chest) portion. Its primary function in the body is to protect vital organs in the thoracic cavity, such as the heart and the lungs. It consists of 12 pairs of ribs with their costal cartilages and the sternum. The ribs are anchored posteriorly to the 12 thoracic vertebrae (T1-T12).
The sternum is the elongated bony structure on the anterior side of the thoracic cage. It consists of three parts: the manubrium, the body, and the xiphoid...
6.3K
The Thoracic Cage: Ribs01:20

The Thoracic Cage: Ribs

9.0K
Ribs are curved, flattened bones forming the thoracic cavity wall with the thoracic muscles. There are 12 pairs of thoracic ribs. The posterior ends of all the ribs articulate with the T1–T12 thoracic vertebrae. In contrast,the anterior ends of most ribs attach to the sternum via their costal cartilages.
Parts of a Typical Rib
A typical rib has a head, neck, and body. The posterior end of the rib is called the head, followed by a narrow neck. The head articulates primarily with the costal...
9.0K
Pressure Relationships in Thoracic Cavity01:24

Pressure Relationships in Thoracic Cavity

6.8K
Breathing, otherwise known as pulmonary ventilation, is the process of air movement into and out of the lungs. The main mechanisms propelling pulmonary ventilation are atmospheric pressure (Patm), intra-pulmonary (Ppul ) or intra-alveolar pressure (Palv) within the alveoli, and intrapleural pressure (Pip) within the pleural cavity.
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs...
6.8K
Frequency-dependent Selection01:21

Frequency-dependent Selection

24.2K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K
Drug Dependence01:17

Drug Dependence

1.7K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Untargeted Sweat Metabolomics and Targeted Plasma Amino Acid Profiling Reveal Dynamic Metabolic Remodeling During Conditioning in <i>Yili</i> Horses.

Biology·2026
Same author

Efficacy of a Novel Ultrasound-Guided C8 Dorsal Root Ganglion Puncture Approach and Radiofrequency Treatment for Postherpetic Neuralgia.

Journal of pain research·2026
Same author

Identification of candidate genes and metabolites associated with lactation performance in Kazakh mares using blood multi-omics and machine learning.

BMC genomics·2026
Same author

Metabolomic insights into flavonoid migration and bioactivity enhancement in Apocynum venetum tea during hot-water brewing.

Food chemistry·2026
Same author

Long-term light grazing facilitates topsoil carbon accumulation in desert steppes by disrupting preferential flow networks.

Journal of environmental management·2026
Same author

Feasibility of left subcostal single-incision laparoscopic surgery for pediatric left retroperitoneal space-occupying lesions.

Pediatric surgery international·2026

Related Experiment Video

Updated: Feb 13, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1&#946; in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

21.4K

STF083010 Mitigates Thoracic Aortic Dissection by Modulating the NLRP3 Inflammasome-Dependent Pyroptosis.

Chen Meng1, Dandan Zhao1, Meiling Shu1

  • 1Human Phenome Institute, Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Centre, Zhangjiang Fudan International Innovation Center, Fudan University, Shanghai, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|February 12, 2026
PubMed
Summary

The small molecule STF083010 effectively prevents thoracic aortic dissection (TAD) by targeting the IRE1α-XBP1s pathway. This novel therapeutic approach also protects vascular smooth muscle cells from inflammation and phenotypic switching, offering new hope for aortic disease treatment.

Keywords:
STF083010VSMCs phenotypic switchingpyroptosisthoracic aortic dissectionvascular inflammation

More Related Videos

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
08:33

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Published on: August 24, 2019

8.1K
Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

11.3K

Related Experiment Videos

Last Updated: Feb 13, 2026

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1&#946; in Human Monocyte-derived Dendritic Cells
09:04

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells

Published on: May 22, 2014

21.4K
Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
08:33

Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm

Published on: August 24, 2019

8.1K
Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
06:52

Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages

Published on: May 21, 2018

11.3K

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Vascular Pathology

Background:

  • Thoracic aortic dissection (TAD) is a critical vascular condition with limited treatment options.
  • The therapeutic role of IRE1α RNase-specific inhibitors, like STF083010, in TAD remains unexplored.

Purpose of the Study:

  • To investigate the therapeutic potential of STF083010 in preventing and treating thoracic aortic dissection (TAD).
  • To elucidate the mechanism by which STF083010 affects the IRE1α-XBP1s axis, vascular smooth muscle cell (VSMC) phenotype, and inflammation in TAD.

Main Methods:

  • Utilized a β-aminopropionitrile monofumarate (BAPN)-induced murine model of TAD.
  • Employed interleukin 1β (IL1β)-stimulated vascular smooth muscle cells (VSMCs) in vitro.
  • Systematically assessed the impact of STF083010 on TAD development, VSMC phenotypic switching, and vascular inflammation.

Main Results:

  • STF083010 administration significantly reduced the incidence and severity of TAD in vivo.
  • STF083010 protected VSMCs against IL1β-induced inflammation and phenotypic switching.
  • Mechanistically, STF083010 inhibited the IRE1α-XBP1s axis, suppressed NLRP3 inflammasome activation-dependent pyroptosis, and reduced VSMC inflammatory activation.

Conclusions:

  • STF083010 demonstrates significant therapeutic potential for preventing thoracic aortic dissection (TAD).
  • The drug acts by modulating the IRE1α-XBP1s pathway and NLRP3 inflammasome, thereby controlling VSMC phenotype and inflammation.
  • STF083010 offers a promising novel therapeutic strategy for aortic pathologies.