Related Experiment Video

Updated: Jul 15, 2025

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
08:28

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

Published on: March 10, 2020

6.9K

Risk Factors of Congenital Heart Defects among Bangladeshi Population

M A Mamun1, M Hussain, K E Khan

  • 1Dr Mohammad Abdullah Al Mamun, Associate Professor, Division of Neonatal Cardiology, Department of Paediatric Cardiology, Bangladesh Shishu Hospital & Institute, Dhaka, Bangladesh;

Mymensingh Medical Journal : MMJ
|October 1, 2023
PubMed

Insights

Environmental factors like maternal illiteracy, rural residence, low socioeconomic status, consanguinity, passive smoking, and stress are linked to congenital heart defects (CHDs). Addressing these modifiable risks may aid in CHD prevention.

Area of Science:

  • Cardiology
  • Public Health
  • Pediatrics

Background:

  • Congenital heart defects (CHDs) have complex etiologies involving genetic and environmental factors.
  • Identifying modifiable environmental risk factors is crucial for CHD prevention strategies.
  • Previous research indicates a potential link between environmental exposures and CHD development.

Purpose of the Study:

  • To investigate the association between various environmental risk factors and the occurrence of CHDs.
  • To identify specific modifiable factors that contribute to the development of CHDs in a Bangladeshi population.

Main Methods:

  • A case-control study was conducted involving parents of children with and without CHDs.
  • Data were collected via face-to-face interviews using a structured questionnaire.
  • Statistical analysis was performed using SPSS version 21.0 to determine significant associations.

Main Results:

  • CHDs were significantly higher in rural populations, children of illiterate mothers, and those from lower socioeconomic backgrounds.
  • Consanguinity and maternal exposure to passive smoking and stress during pregnancy were significantly associated with increased CHD risk.
  • No significant association was found between maternal drug use or infections during pregnancy and CHDs.

Conclusions:

  • Maternal illiteracy, rural residence, low socioeconomic status, consanguinity, passive smoking, and stress during pregnancy are significant risk factors for CHDs.
  • These findings highlight the importance of addressing socioeconomic and environmental factors for CHD prevention.
  • Further research and targeted interventions are needed to mitigate these identified risks.

More Related Videos

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

11.7K
Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts05:58

Using Immunofluorescence to Detect PM2.5-induced DNA Damage in Zebrafish Embryo Hearts

Published on: February 15, 2021

3.9K

Related Concept Videos

Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
14
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
12
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K
Probability Laws01:49

Probability Laws

Overview
41.0K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
14
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
15