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Estro G-100 herbal extract and hot flashes in postmenopausal women: A randomized double-blinded controlled trial
Farah Farzaneh1, Golnaz Fallah1, Ahmad Khalili-Chelik2
1Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objective:
The present study aimed to determine the efficacy of EstroG-100 herbal extract on hot flashes in postmenopausal women.
Material And Methods:
This randomized, double-blind, placebo-controlled trial was performed on postmenopausal women recruited from two university hospitals complaining of hot flashes. The intervention group received two extract capsules (daily for 12 weeks), and the control group received two placebo capsules (daily for 12 weeks). Finally, the frequency and severity of hot flashes (F&S) were subjectively reported and compared weekly during the treatment for 12 weeks.
Results:
Out of 120 randomized participants, 35 entered the final analysis for each group. In the third week, participants of the control group significantly reported more moderate hot flashes than other group (MD=1.00, P = 0.004). However, in terms of mild (MD=0.74, P = 0.057) and severe (MD=0.60, P = 0.064) hot flashes, the groups did not differ. In the sixth week, mild (MD=1.51, P<0.001), moderate (MD=1.54, P<0.001), and severe (MD=1.22, P<0.001) hot flashes were significantly reported more in the control group compared with another group.
Conclusion:
The present study revealed that EstroG-100 herbal extract could improve hot flashes in postmenopausal women.
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