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Absolute oral bioavailability of ciprofloxacin
Antimicrobial Agents and Chemotherapy
|September 1, 1986
Summary
Ciprofloxacin, a quinoline carboxylic acid antibiotic, demonstrated reliable oral bioavailability (69%) and rapid absorption in healthy volunteers. Further clinical studies are recommended for this promising antimicrobial agent.
Area of Science:
- Pharmacology
- Clinical Pharmacy
- Antimicrobial Agents
Background:
- Ciprofloxacin is a novel quinoline carboxylic acid with potential antimicrobial applications.
- Understanding its pharmacokinetic profile is crucial for therapeutic efficacy.
Purpose of the Study:
- To determine the absolute bioavailability of oral ciprofloxacin.
- To assess the pharmacokinetic parameters of ciprofloxacin following oral and intravenous administration.
Main Methods:
- A randomized, crossover study involving 12 healthy male volunteers.
- Administration of 200 mg ciprofloxacin orally and intravenously, one week apart.
- Measurement of serum concentrations to determine half-life, clearance, and bioavailability.
Main Results:
- Ciprofloxacin exhibited rapid absorption, with peak serum concentrations at approximately 0.71 hours.
- The absolute oral bioavailability was calculated to be 69% +/- 7%.
- Half-lives were similar for both administration routes (oral: 4.11 h, IV: 4.2 h), with renal clearance accounting for ~60% of serum clearance.
Conclusions:
- Ciprofloxacin is rapidly absorbed and demonstrates reliable bioavailability when administered orally in healthy individuals.
- The pharmacokinetic profile supports its potential as an effective oral antibiotic.
- Further investigation in patient populations is warranted to confirm clinical utility.