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Updated: Jul 15, 2025
Conducting Respiratory Oscillometry in an Outpatient Setting
Published on: April 8, 2022
Medium-term repeatability for airwave oscillometry in patients with severe asthma taking benralizumab
1Scottish Centre for Respiratory Research, Ninewells Hospital and School of Medicine, University of Dundee, Dundee, United Kingdom.
Background:
The effort-independent tidal breathing test used by oscillometry presents a viable alternative for following up patients whose condition is stable while they are receiving biologic therapy.
Objective:
We aimed to determine intrasession and intersession repeatability values for airwave oscillometry (AOS) and spirometry in patients who were already taking benralizumab.
Methods:
In all, 21 patients with severe eosinophilic asthma attended the Scottish Centre for Respiratory Research as part of a clinical trial (EudraCT identification number 2019-003763-22). Paired AOS and spirometry values were obtained at 3 separate visits (baseline and days 28 and 56) with no change in asthma therapy.
Results:
Intrasession agreement between repeated measurements for AOS and spirometry was excellent (intraclass correlation coefficient ≥ 0.90) at all 3 visits. Intersession agreement was also excellent (intraclass correlation coefficient ≥ 0.80).
Conclusion:
In this study we report medium-term intrasession and intersession repeatability values for airwave oscillometry and spirometry in a cohort of severely asthmatic patients receiving benralizumab therapy. Oscillometry can be used to follow up patients with asthma who are taking biologics.
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