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Validation of AI-based software for objectification of conjunctival provocation test.
Yury Yarin1, Alexandra Kalaitzidou1, Kira Bodrova1
1Practice for ENT und Allergology, Dresden, Germany.
The Journal of Allergy and Clinical Immunology. Global
|October 2, 2023
Summary
A new AI tool, AllergoEye, objectively quantifies allergic reactions during conjunctival provocation tests (CPT). This method offers high sensitivity and specificity, improving allergy diagnosis and therapy control.
Area of Science:
- Allergology
- Medical technology
- Artificial intelligence in medicine
Background:
- Provocation tests are vital in allergology for assessing allergen sensitivity.
- Objective quantification of allergic reactions is crucial but often lacking.
- The conjunctival provocation test (CPT) is underutilized due to a lack of objective measurements.
Purpose of the Study:
- To develop and validate AllergoEye, an AI-based method for quantitative evaluation of conjunctival allergic reactions.
- To address the limitations of subjective assessments in CPT.
Main Methods:
- AllergoEye utilizes a smartphone camera for imaging and a PC for AI-driven image analysis.
- A clinical study involved 41 patients undergoing standardized CPT with grass allergens.
- Reactions were assessed using both subjective symptom scores and quantitative AllergoEye scores.
Main Results:
- AllergoEye achieved 98% sensitivity and 90% specificity compared to human evaluation.
- Adjusting thresholds improved AllergoEye's specificity to 97%.
- A significant correlation was found between AllergoEye's quantified sensitivity and specific IgE levels, unlike subjective scores.
Conclusions:
- AllergoEye is a sensitive and efficient tool for objective measurement of allergic reactions in CPT.
- The AI method is suitable for both clinical research and routine patient therapy control.
- Objective quantification enhances the reliability and utility of CPT in allergy management.
