Determination of tissue oxygen saturation by diffuse reflectance spectroscopy

Area of Science:

• Biomedical Engineering
• Medical Diagnostics
• Physiology

Background:

• Tissue oxygenation is vital for assessing human health, especially in diabetic patients with microcirculatory issues.
• Monitoring tissue oxygen saturation aids in identifying peripheral vascular problems.

Purpose of the Study:

• To develop a non-invasive method for measuring tissue oxygen saturation using diffuse reflectance.
• To create an automated technique for rapid and easy medical diagnosis.

Main Methods:

• Implemented a computational algorithm to automate diffuse reflectance measurements.
• Conducted experiments on volunteers, applying vascular occlusion to observe changes in tissue oxygen saturation.

Main Results:

• Tissue oxygen saturation decreased progressively with increased vascular occlusion pressure.
• The developed technique demonstrated effectiveness in monitoring blood hemodynamics.

Conclusions:

• Successfully developed a non-invasive, in vivo methodology for tissue oxygen saturation measurement.
• The technique is fast, requires low computational cost, and provides objective, quantifiable evaluations.
• This method is suitable for monitoring compromised tissue oxygenation in various pathologies.