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Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

157
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
157
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

357
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
357
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

256
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
256
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

257
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
257
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

194
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
194
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

3.9K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Related Experiment Video

Updated: Jul 15, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
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A Case of Tuberculosis Cutis Orificialis.

XiaoYan Zhang1, Jifeng Liu1

  • 1Department of Dermatology, Hangzhou Third People's Hospital, Affiliated Hangzhou Dermatology Hospital of Zhejiang University School of Medicine, Hangzhou, People's Republic of China.

Clinical, Cosmetic and Investigational Dermatology
|October 2, 2023
PubMed
Summary

A chronic tuberculosis patient developed painful anal ulcers due to the spread of infection. Microscopic examination confirmed Tuberculosis cutis orificialis, affecting the skin and intestines.

Keywords:
skin ulcerstuberculosistuberculosis cutis orificialis

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Area of Science:

  • Dermatology
  • Gastroenterology
  • Infectious Diseases

Background:

  • Tuberculosis (TB) is a significant global health concern.
  • Chronic TB can lead to disseminated or extrapulmonary manifestations.
  • Cutaneous involvement in TB, though less common, presents diagnostic challenges.

Observation:

  • A 49-year-old male with a history of chronic pulmonary tuberculosis presented with eight months of painful perianal ulcers.
  • Colonoscopy revealed ulcerations in the transverse colon.
  • Microscopic examination confirmed ulcerations in both the skin and intestine.

Findings:

  • The perianal skin ulcer tested positive for Mycobacterium tuberculosis bacilli.
  • The diagnosis was established as Tuberculosis cutis orificialis.
  • Evidence suggested a contiguous spread of TB from the lungs to the intestines and then to the skin.

Implications:

  • This case highlights the importance of considering disseminated TB in patients with chronic pulmonary disease and unusual skin lesions.
  • Tuberculosis cutis orificialis, a rare manifestation, requires prompt diagnosis and appropriate anti-TB treatment.
  • Understanding the pathway of infection spread is crucial for effective patient management and preventing further complications.