Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cycloaddition Reactions: MO Requirements for Thermal Activation01:16

Cycloaddition Reactions: MO Requirements for Thermal Activation

3.6K
Thermal cycloadditions are reactions where the source of activation energy needed to initiate the reaction is provided in the form of heat. A typical example of a thermally-allowed cycloaddition is the Diels–Alder reaction, which is a [4 + 2] cycloaddition. In contrast, a [2 + 2] cycloaddition is thermally forbidden.
3.6K
Network Covalent Solids02:18

Network Covalent Solids

13.5K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
13.5K
Chemical and Solubility Equilibria02:21

Chemical and Solubility Equilibria

4.1K
The free energy change associated with dissolving a solute in a liter of solvent is called the free energy of a solution, ΔGsolution. The overall ΔGsolution is expressed as the balance of ΔGinteraction against the always-favorable free-energy of mixing, ΔGmixing. Solution formation is favorable if  ΔGsolution is less than zero, whereas it is unfavorable if ΔGsolution is greater than zero. In short, for a solution to form and complete dissolution to take place,...
4.1K
Phase II Conjugation Reactions: Overview01:14

Phase II Conjugation Reactions: Overview

230
Conjugation, a key component of phase II biotransformation reactions, is a vital process in drug detoxification. It involves transferring endogenous substances like glucuronic acid, sulfate, and glycine to drugs or their metabolites formed in phase I reactions. These conjugation reactions, often catalyzed by specific enzymes, transform potentially harmful metabolites into inactive, water-soluble forms easily excreted in urine or bile. By enhancing polarity and eliminating pharmacological...
230

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Deep-Red Emissive Cage-in-Rings Complex for Lysosome Imaging.

Angewandte Chemie (International ed. in English)·2026
Same author

Lipopolysaccharide hydrolysis-targeting nano-chimeras detoxify endotoxin through specific adsorption and efficient degradation.

Nature communications·2026
Same author

Adaptive Cavity-Enabled Crystalline Chirality in Nanocarbon Cages.

Angewandte Chemie (International ed. in English)·2026
Same author

A Self-Assembled Cage Binds Xenon via Xe-F Dispersion Interactions.

Journal of the American Chemical Society·2026
Same author

Synthesis and guest inclusion for molecular catcher-based structure determination.

Nature protocols·2026
Same author

Lanthanide-doped nanocrystals enable organic room-temperature phosphorescence in solution through direct triplet excitation.

Nature chemistry·2026

Related Experiment Video

Updated: Jul 15, 2025

Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
10:39

Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction

Published on: August 23, 2018

7.9K

Applications of macrocycle-based solid-state host-guest chemistry.

Huangtianzhi Zhu1,2, Liya Chen1,2, Bin Sun1,2

  • 1Stoddart Institute of Molecular Science, Department of Chemistry, Zhejiang University, Hangzhou, P. R. China.

Nature Reviews. Chemistry
|October 2, 2023
PubMed
Summary
This summary is machine-generated.

Solid-state macrocyclic chemistry offers robust host-guest complexes with enhanced binding affinities. This approach improves stability and processability for applications in separation science and advanced devices.

More Related Videos

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions
10:22

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions

Published on: June 16, 2014

18.2K
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

6.9K

Related Experiment Videos

Last Updated: Jul 15, 2025

Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction
10:39

Heterogeneous Removal of Water-Soluble Ruthenium Olefin Metathesis Catalyst from Aqueous Media Via Host-Guest Interaction

Published on: August 23, 2018

7.9K
In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions
10:22

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions

Published on: June 16, 2014

18.2K
Solid-phase Synthesis of [4.4] Spirocyclic Oximes
05:15

Solid-phase Synthesis of [4.4] Spirocyclic Oximes

Published on: February 6, 2019

6.9K

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Physical Chemistry

Background:

  • Macrocyclic molecules exhibit valuable guest binding properties in solution-phase host-guest chemistry.
  • Solution-phase complexes face limitations in stability and processability, hindering broader applications.
  • Transitioning host-guest chemistry to the solid state offers enhanced robustness and affinity.

Purpose of the Study:

  • To review recent advancements in macrocycle-based solid-state host-guest chemistry.
  • To discuss the fundamental physical chemistry governing these solid-state complexes.
  • To explore representative macrocycles, their complexes, and potential applications.

Main Methods:

  • Literature review of macrocycle-based solid-state host-guest chemistry.
  • Analysis of physical chemistry principles for solid-state complex formation.
  • Exploration of specific macrocyclic systems and their guest encapsulation capabilities.

Main Results:

  • Solid-state macrocyclic complexes demonstrate superior guest binding affinities compared to their solution-phase counterparts.
  • Enhanced stability and processability are key advantages of solid-state host-guest systems.
  • Macrocyclic compounds in the solid state are suitable for separation science and device applications.

Conclusions:

  • Solid-state macrocycle-based host-guest chemistry presents a promising avenue for developing advanced materials.
  • The increased affinity and robustness of these complexes open new application possibilities.
  • Further research into perspectives and challenges is essential for future development.