Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Homotypic dendritic interactions constrain growth and receptor distribution in Drosophila T4 neurons without affecting orientation or function.

Development (Cambridge, England)·2026
Same author

Population Morphology Implies a Common Developmental Blueprint for <i>Drosophila</i> Motion Detectors.

bioRxiv : the preprint server for biology·2025
Same author

Polyadic synapses introduce unique wiring architectures in T5 cells of Drosophila.

PloS one·2025
Same author

Differential temporal filtering in the fly optic lobe.

Journal of computational neuroscience·2025
Same author

Columnar cholinergic neurotransmission onto T5 cells of Drosophila.

Current biology : CB·2025
Same author

Biased cell adhesion organizes the Drosophila visual motion integration circuit.

Developmental cell·2024

Related Experiment Video

Updated: Jul 15, 2025

Electrophysiological Method for Recording Intracellular Voltage Responses of Drosophila Photoreceptors and Interneurons to Light Stimuli In Vivo
11:42

Electrophysiological Method for Recording Intracellular Voltage Responses of Drosophila Photoreceptors and Interneurons to Light Stimuli In Vivo

Published on: June 19, 2016

19.6K

Multilevel visual motion opponency in Drosophila.

Georg Ammer1, Etienne Serbe-Kamp2,3, Alex S Mauss2

  • 1Max Planck Institute for Biological Intelligence, Martinsried, Germany. georg.ammer@bi.mpg.de.

Nature Neuroscience
|October 2, 2023
PubMed
Summary

Researchers uncovered multilevel opponent inhibition in the fly visual system, revealing a circuit where one cell type mediates direction-selective, motion-opponent inhibition across network levels for enhanced sensory processing.

More Related Videos

Visually Mediated Odor Tracking During Flight in Drosophila
08:50

Visually Mediated Odor Tracking During Flight in Drosophila

Published on: January 26, 2009

10.0K
Video-oculography in Mice
09:43

Video-oculography in Mice

Published on: July 19, 2012

23.8K

Related Experiment Videos

Last Updated: Jul 15, 2025

Electrophysiological Method for Recording Intracellular Voltage Responses of Drosophila Photoreceptors and Interneurons to Light Stimuli In Vivo
11:42

Electrophysiological Method for Recording Intracellular Voltage Responses of Drosophila Photoreceptors and Interneurons to Light Stimuli In Vivo

Published on: June 19, 2016

19.6K
Visually Mediated Odor Tracking During Flight in Drosophila
08:50

Visually Mediated Odor Tracking During Flight in Drosophila

Published on: January 26, 2009

10.0K
Video-oculography in Mice
09:43

Video-oculography in Mice

Published on: July 19, 2012

23.8K

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Sensory Systems

Background:

  • Inhibitory interactions are common in neural circuits, but their mechanisms are often unknown.
  • Opponent inhibition, crucial for sensory processing, lacks detailed circuit and biophysical understanding.

Purpose of the Study:

  • To elucidate the multilevel circuit architecture and mechanisms of opponent inhibition in the fly visual system.
  • To investigate how this inhibition is implemented at cellular and network levels.

Main Methods:

  • Optogenetics and voltage/calcium imaging for activity monitoring.
  • Connectomics for synaptic wiring analysis.
  • Electrophysiology and computational modeling for functional characterization.

Main Results:

  • A single cell type mediates direction-selective, motion-opponent inhibition across three network levels.
  • Inhibition is mediated by GluClα receptors and balanced with excitation, despite fewer synapses.
  • A hierarchical structure distributes computation, preventing gain reduction.

Conclusions:

  • The fly visual system employs a nested, hierarchical circuit for opponent inhibition.
  • This architecture enhances noise resilience and sensory information selectivity.
  • Understanding these mechanisms provides insights into neural computation across species.