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Updated: Jul 15, 2025

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Surgical Treatment for Benign Prostatic Hyperplasia: Holmium Laser Enucleation of the Prostate HoLEP.
Published on: March 6, 2018
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Does Resectoscope Sheath Size Influence Holmium Laser Enucleation of the Prostate Outcomes? A Prospective Randomized
Nicholas S Dean1,2, Matthew S Lee1,3, Mark A Assmus1,4
1Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Journal of Endourology
|October 3, 2023
Summary
Holmium laser enucleation of the prostate (HoLEP) scope size did not impact surgical duration or complications. However, the 28F scope improved surgeon visibility and patient outcomes like same-day trial of void and shorter length of stay.
Area of Science:
- Urology
- Minimally Invasive Surgery
- Surgical Technology
Background:
- Holmium laser enucleation of the prostate (HoLEP) is a standard treatment for benign prostatic hyperplasia.
- The choice of scope size (24F vs. 28F) is debated, with larger scopes potentially offering better flow and visibility, while smaller scopes may be less traumatic.
Purpose of the Study:
- To compare the outcomes of ambulatory HoLEP using 24F and 28F laser scopes.
- To evaluate the impact of scope size on surgical duration, surgeon experience, and postoperative patient results.
Main Methods:
- A randomized controlled trial comparing 24F and 28F scopes in patients undergoing HoLEP for prostates <200 cm³.
- Primary outcome: surgical duration. Secondary outcomes: surgeon-reported scope performance, same-day trial of void (SDTOV), length of stay (LOS), same-day discharge (SDD), and 90-day complications.
Main Results:
- No significant differences in patient characteristics, procedural duration, or efficiencies between the 24F and 28F groups.
- The 28F scope demonstrated improved surgeon-graded irrigation flow and visibility (p < 0.001).
- Patients in the 28F group had higher rates of effective SDTOV (94.3% vs. 82.1%, p = 0.048) and shorter LOS (7.0 vs. 11.9 hours, p = 0.014), but SDD rates were not statistically different.
Conclusions:
- Scope size (24F vs. 28F) in HoLEP did not reveal clear intraoperative or postoperative advantages at 3-month follow-up.
- The 28F scope may be beneficial for shortening LOS and increasing SDTOV rates when same-day discharge is a goal.

