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Evaluating interleukin-6 levels and the rs1800795 variant in Turkish patients with COVID-19: a prospective cohort

Ozlem Sezer1, Ayse Feyda Nursal2, Ozgur Gunal3

  • 1Department of Medical Genetics, Faculty of Medicine, Samsun University, Samsun, Turkey.

Nucleosides, Nucleotides & Nucleic Acids
|October 3, 2023
PubMed

Insights

The interleukin 6 (IL6) rs1800795 variant is associated with COVID-19 susceptibility in Turkish patients. Higher frequencies of the IL6 rs1800795 GG genotype and G allele were observed in positive cases and asymptomatic individuals.

Area of Science:

  • Genetics
  • Immunology
  • Infectious Diseases

Background:

  • Coronavirus disease 2019 (COVID-19) is a significant multisystem illness.
  • Interleukin-6 (IL-6) is a key cytokine influencing inflammation and immune responses.

Purpose of the Study:

  • To investigate the association between the interleukin 6 (IL6) rs1800795 genetic variant and IL-6 levels in Turkish COVID-19 patients.
  • To explore the correlation of this variant with disease severity and clinical presentation.

Main Methods:

  • A prospective cohort study involving 148 real-time RT-PCR and/or CT-confirmed COVID-19 patients.
  • IL6 rs1800795 genotyping using PCR-RFLP and serum IL-6 measurement via ELISA.
  • Patients were categorized into asymptomatic, symptomatic, and intensive care unit groups.

Main Results:

  • Increased IL6 rs1800795 GG genotype and G allele frequencies were found in PCR-positive patients compared to PCR-negative individuals (p < 0.000).
  • The GG genotype and G allele were more prevalent in asymptomatic patients and CT-negative patients.
  • Elevated serum IL-6 levels were observed in asymptomatic patients.

Conclusions:

  • The IL6 rs1800795 variant may play a role in COVID-19 susceptibility among individuals of Turkish descent.
  • Further large-scale studies across diverse genetic populations are warranted to validate these findings.
Abstract

Keywords:
Covıd-19interleukin 6real-time polymerase chain reactionvariant

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