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Related Experiment Video

Updated: Jul 15, 2025

Three-dimensional Printing of Thermoplastic Materials to Create Automated Syringe Pumps with Feedback Control for Microfluidic Applications
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Technical note: 3D-printed MRI-compatible syringe pump.

Martin D Holland1, Seth Lee2, Harrison Kim2

  • 1Interdisciplinary Engineering, The University of Alabama at Birmingham, Birmingham, Alabama, USA.

Medical Physics
|October 3, 2023
PubMed
Summary
This summary is machine-generated.

This study developed a cost-effective, MRI-compatible syringe pump (MSP) for simultaneous multi-subject contrast agent delivery. The portable MSP reliably infuses agents inside the MRI bore during scans.

Keywords:
3D printingMRIsyringe pump

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Area of Science:

  • Medical Imaging Technology
  • Biomedical Engineering
  • Radiology

Background:

  • Conventional power injectors for MRI contrast agents are expensive and single-subject.
  • Existing multi-syringe pumps are non-MRI compatible, requiring remote placement.
  • There is a need for an affordable, in-bore solution for multi-subject injections.

Purpose of the Study:

  • To develop a prototype of a cost-effective, user-friendly, and reliable syringe pump for in-bore MRI use.
  • To enable simultaneous contrast agent delivery to multiple subjects during a scan.
  • To overcome the limitations of current MRI injection systems.

Main Methods:

  • Designed and 3D-printed an MRI-compatible syringe pump (MSP) capable of infusing up to three syringes.
  • Controlled injection speed using interchangeable gear sets and adjustable hairspring length.
  • Evaluated injection rates across three gear ratios and ten hairspring lengths, calculating mean and standard deviation.

Main Results:

  • Achieved volume injection rates of 0.209 ± 0.003 mL/s, 0.411 ± 0.002 mL/s, and 0.625 ± 0.006 mL/s with different gear ratios.
  • Demonstrated precise control over injection rates, with high correlation (r > 0.96) and low p-values (< 0.001) across adjustments.
  • Reported a low coefficient of variation (0.727 ± 0.346%) in injection rate measurements, indicating reliability.

Conclusions:

  • The developed MRI-compatible syringe pump (MSP) is a portable and reliable device.
  • The MSP enables simultaneous liquid agent delivery to multiple subjects within the MRI bore during scanning.
  • This technology offers a cost-effective and practical solution for advanced MRI procedures.