Related Experiment Video
Updated: Jul 15, 2025
Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
Published on: March 3, 2023
Himalayan flora: targeting various molecular pathways in lung cancer
Abija James1, K Akash1, Avinash Sharma1
1Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, Himachal Pradesh, 173229, India.
Abstract:
The fatal amplification of lung cancer across the globe and the limitations of current treatment strategies emphasize the necessity for substitute therapeutics. The incorporation of phyto-derived components in chemo treatment holds promise in addressing those challenges. Despite the significant progressions in lung cancer therapeutics, the complexities of molecular mechanism and pathways underlying this disease remain inadequately understood, necessitating novel biomarker targeting. The Himalayas, abundant in diverse plant varieties with established chemotherapeutic potential, presents a promising avenue for investigating potential cures for lung carcinoma. The vast diversity of phytocompounds herein can be explored for targeting the disease. This review delves into the multifaceted targets of lung cancer and explores the established phytochemicals with their specific molecular targets. It emphasizes comprehending the intricate pathways that govern effective therapeutic interventions for lung cancer. Through this exploration of Himalayan flora, this review seeks to illuminate potential breakthroughs in lung cancer management using natural compounds. The amalgamation of Himalayan plant-derived compounds with cautiously designed combined therapeutic approaches such as nanocarrier-mediated drug delivery and synergistic therapy offers an opportunity to redefine the boundaries of lung cancer treatment by reducing the drug resistance and side effects and enabling an effective targeted delivery of drugs. Furthermore, additional studies are obligatory to understand the possible derivation of natural compounds used in current lung cancer treatment from plant species within the Himalayan region.
Insights
Lung cancer requires new treatments due to limited options. Himalayan plants offer promising phytochemicals for novel lung cancer therapies, potentially improving drug delivery and reducing side effects.
Area of Science:
- Phytochemistry
- Oncology
- Pharmacology
Background:
- Global rise in lung cancer necessitates alternative treatments.
- Current lung cancer therapies face limitations and incompletely understood molecular mechanisms.
- Phytochemicals show potential as complementary or alternative lung cancer treatments.
Purpose of the Study:
- To review lung cancer targets and phytochemicals from Himalayan flora.
- To explore molecular pathways for effective lung cancer intervention.
- To highlight potential of natural compounds in lung cancer management.
Main Methods:
- Literature review of lung cancer molecular targets.
- Analysis of phytochemicals from Himalayan plants and their mechanisms.
- Exploration of combined therapeutic strategies, including nanocarriers.
Main Results:
- Himalayan flora contains diverse phytochemicals with potential anti-lung cancer activity.
- Specific molecular targets and pathways for phytochemical intervention identified.
- Combined approaches like nanocarrier-mediated delivery show promise for enhanced efficacy.
Conclusions:
- Himalayan phytochemicals represent a valuable resource for novel lung cancer therapeutics.
- Understanding molecular pathways is crucial for developing effective natural compound-based treatments.
- Further research is needed to integrate these findings into clinical practice and explore compound origins.
