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Causal association between placental growth factor and coronary heart disease: a Mendelian randomization study

Bo Zuo1, Sha Zhu2, Guoting Zhong2

  • 1Department of Cardiology, Cardiovascular Centre, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Aging
|October 3, 2023
PubMed

Insights

Placental growth factor (PlGF) is causally linked to a reduced risk of coronary heart disease (CHD). This genetic association suggests PlGF may be a therapeutic target for preventing heart conditions like myocardial infarction.

Area of Science:

  • Cardiovascular Genetics
  • Molecular Cardiology
  • Biomarkers in Heart Disease

Background:

  • Placental growth factor (PlGF) is a polypeptide hormone involved in physiological processes.
  • Observational studies suggest an association between PlGF and coronary heart disease (CHD) risk.
  • The causal relationship between PlGF and CHD remains unclear.

Purpose of the Study:

  • To investigate the causal association between genetically predicted PlGF levels and the risk of CHD.
  • To utilize Mendelian randomization to assess genetic links between PlGF and cardiovascular events.

Main Methods:

  • Employed two-sample Mendelian randomization (MR).
  • Selected single nucleotide polymorphisms (SNPs) associated with PlGF as instrumental variables (IVs).
  • Evaluated the causal effect of genetically predicted PlGF on CHD risk.

Main Results:

  • A suggestive causal association was found between genetically predicted PlGF levels and overall CHD risk (OR = 0.79).
  • Significant negative causal associations were observed for myocardial infarction (OR = 0.83) and unstable angina pectoris (OR = 0.78).
  • PlGF levels showed a negative correlation with CHD events (OR = 0.89).

Conclusions:

  • Genetically predicted PlGF levels are causally associated with a reduced risk of CHD, particularly acute coronary syndrome.
  • PlGF emerges as a potential therapeutic target for managing and preventing coronary heart disease.
Abstract

Keywords:
Mendelian randomizationcausal associationcoronary heart diseasemyocardial infarctionplacental growth factor

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