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Related Experiment Video

Updated: Jul 15, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
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Incorporating entity-level knowledge in pretrained language model for biomedical dense retrieval.

Jiajie Tan1, Jinlong Hu1, Shoubin Dong1

  • 1Guangdong Key Lab of Computer Network, School of Computer Science and Engineering, South China University of Technology, Guangzhou, China.

Computers in Biology and Medicine
|October 3, 2023
PubMed
Summary

This study introduces ELK, a novel method enhancing biomedical dense retrieval by integrating external knowledge graph embeddings. ELK improves search result ranking and maintains efficient query processing.

Keywords:
Dense retrievalKnowledge graphNatural language processingSemantic matching

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Area of Science:

  • Biomedical Natural Language Processing (NLP)
  • Information Retrieval
  • Machine Learning

Background:

  • Pre-trained language models (PLMs) excel in NLP but struggle with biomedical entity ambiguity in dense retrieval.
  • Existing PLM-based dense retrieval methods require improvement for the diverse biomedical domain.

Purpose of the Study:

  • To enhance dense retrieval performance in the biomedical domain by bridging the semantic gap.
  • To enrich query and document representations using external knowledge at the entity level.

Main Methods:

  • Incorporated entity-level external knowledge into a BERT-based dense retrieval model.
  • Introduced additional self-attention and information interaction modules for fusing text and entity embeddings.
  • Developed an entity similarity loss and a weighted entity concatenation mechanism.

Main Results:

  • The proposed method (ELK) significantly outperforms state-of-the-art dense retrieval techniques on two biomedical datasets.
  • ELK achieved at least a 5% improvement in NDCG metrics compared to coCondenser.
  • ELK demonstrated competitive query latency despite its enhanced architecture.

Conclusions:

  • Integrating external knowledge effectively addresses the semantic gap in biomedical dense retrieval.
  • ELK offers a robust and efficient solution for improving biomedical information retrieval.
  • The method shows promise for advancing NLP applications in specialized scientific domains.