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Sharing and Reusing Computable Phenotype Definitions.

Shyam Visweswaran1,2, Louisa Yu Zhang3, Kevin Bui1

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Summary
This summary is machine-generated.

A new tool, Sharephe, enables easy sharing and reuse of computable phenotype definitions. This facilitates electronic health record reuse for research and cohort identification across institutions.

Keywords:
clinical data warehousecohort identificationcomputable phenotypeelectronic health record

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Area of Science:

  • Biomedical Informatics
  • Health Data Science
  • Clinical Research Informatics

Background:

  • Scalable sharing and reuse of computable phenotype definitions are crucial for leveraging electronic health records (EHRs).
  • Efficient EHR reuse supports cohort identification and clinical research studies.
  • Standardized phenotype definitions enhance data interoperability and research reproducibility.

Approach:

  • Developed Sharephe, a tool integrating a cloud-based repository with the Informatics for Integrating Biology and the Bedside (i2b2) platform.
  • Sharephe offers a plugin for i2b2, enabling phenotype creation, evaluation, and implementation without complex query language knowledge.
  • The system supports importing/exporting phenotypes and linking to metadata, facilitating data management and provenance tracking.

Key Points:

  • Sharephe provides a cloud-based, searchable repository for computable phenotypes.
  • The tool allows seamless import and export of phenotype definitions.
  • Metadata linking enhances the context and usability of shared phenotypes.
  • Initial evaluation on the Evolve to Next-Gen ACT (ENACT) network demonstrated successful phenotype creation, sharing, and reuse across multiple sites.

Conclusions:

  • The integration of a cloud-based repository with an i2b2 plugin facilitates phenotype storage and retrieval.
  • Sharephe enables researchers to access and utilize phenotypes from any location, at any time.
  • Cross-site collaboration within research networks is significantly enhanced through this shared platform.