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CNS Repopulation by Hematopoietic-Derived Microglia-Like Cells Corrects Progranulin deficiency

Pasqualina Colella1, Ruhi Sayana1, Maria Valentina Suarez-Nieto1

  • 1Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, 94305.

Research Square
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PubMed
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Hematopoietic stem cell transplantation can deliver therapies to the CNS. A new conditioning regimen using Busulfan and PLX3397 enables efficient microglia replacement, showing therapeutic potential in a GRN deficiency model.

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