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She didn't start the fire: Mammary duct epithelial cells suppress adipocyte thermogenesis
1Department of Medicine, Division of Endocrinology, University of Pennsylvania, Philadelphia, PA, USA.
Cell Metabolism
|October 4, 2023
Abstract:
Male and female mice display highly divergent responses to cold-induced thermogenic beiging of subcutaneous adipose tissues. Recently in Nature, Patel et al. showed that mammary duct epithelial cells respond to cold-induced sympathetic activity, triggering the secretion of lipocalin 2 (LCN2) to inhibit thermogenic differentiation of adjacent mammary adipocytes.

