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The histopathology of enteric infection with Yersinia pseudotuberculosis

N R El-Maraghi, N S Mair

    American Journal of Clinical Pathology
    |June 1, 1979
    PubMed

    Insights

    Yersinia pseudotuberculosis infections primarily affect young males, often mimicking appendicitis. The study details the pathology, revealing mesenteric lymphadenitis and characteristic granulomas, with most cases resolving without antibiotics.

    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Pathology

    Background:

    • Enteric infections caused by Yersinia pseudotuberculosis can present with symptoms similar to acute appendicitis.
    • Understanding the pathological changes is crucial for accurate diagnosis and management.

    Purpose of the Study:

    • To describe the gross and microscopic pathological findings in 70 cases of Yersinia pseudotuberculosis infection.
    • To correlate clinical presentation with pathological findings and discuss pathogenesis and differential diagnosis.

    Main Methods:

    • Analysis of 70 serologically confirmed cases of Yersinia pseudotuberculosis infection.
    • Examination of surgical specimens including mesenteric lymph nodes, appendices, terminal ileums, and ascending colons.
    • Histological evaluation to identify distinct stages of the disease.

    Main Results:

    • Highest incidence observed in young males; serologic O-group I was the most common infecting organism.
    • Mesenteric lymphadenitis was the most consistent finding at laparotomy, often resembling acute appendicitis.
    • Histology revealed four stages, characterized by granulomas with central necrosis, microabscesses, and potential mucosal ulceration.

    Conclusions:

    • Yersinia pseudotuberculosis infection typically presents as mesenteric lymphadenitis, mimicking appendicitis.
    • The disease usually follows a benign course, often not requiring antibiotic treatment.
    • Characteristic granulomatous inflammation is a key pathological feature.

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