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Dermatophyte resistance - on the rise.
Ivan R Bristow1, Lovleen Tina Joshi2
1AECC University College, Parkwood Campus, Parkwood Road, Bournemouth, BH5 2DF, UK. mail@ibristow.com.
Journal of Foot and Ankle Research
|October 4, 2023
Summary
New dermatophyte strains resistant to terbinafine are spreading globally. Urgent research and practice changes are needed to manage this growing antifungal resistance crisis.
Area of Science:
- Medical Mycology
- Antimicrobial Resistance
Background:
- Dermatophytes are fungi thriving on keratinized tissues of humans and animals.
- Emerging dermatophyte strains exhibit resistance to terbinafine and other antifungal drugs.
- Reports of resistant strains originated in Asia and have spread worldwide.
Discussion:
- Mechanisms driving this emerging antifungal resistance remain largely unknown.
- The global dissemination of resistant dermatophyte strains poses a significant public health concern.
- Current management strategies may be inadequate against these resilient fungal infections.
Key Insights:
- Identification of novel antifungal resistance mechanisms in dermatophytes is critical.
- Understanding the epidemiology of resistant dermatophyte spread is essential for control.
- Development of new diagnostic and therapeutic approaches is urgently required.
Outlook:
- Further research into dermatophyte resistance is vital for effective treatment.
- Clinical practice must adapt to address the challenge of antifungal drug resistance.
- Global collaboration is necessary to contain and manage the spread of resistant infections.
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