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Dermatophyte resistance - on the rise

Ivan R Bristow1, Lovleen Tina Joshi2

  • 1AECC University College, Parkwood Campus, Parkwood Road, Bournemouth, BH5 2DF, UK. mail@ibristow.com.

Journal of Foot and Ankle Research
|October 4, 2023
PubMed

Insights

New dermatophyte strains resistant to terbinafine are spreading globally. Urgent research and practice changes are needed to manage this growing antifungal resistance crisis.

Area of Science:

  • Medical Mycology
  • Antimicrobial Resistance

Background:

  • Dermatophytes are fungi thriving on keratinized tissues of humans and animals.
  • Emerging dermatophyte strains exhibit resistance to terbinafine and other antifungal drugs.
  • Reports of resistant strains originated in Asia and have spread worldwide.

Discussion:

  • Mechanisms driving this emerging antifungal resistance remain largely unknown.
  • The global dissemination of resistant dermatophyte strains poses a significant public health concern.
  • Current management strategies may be inadequate against these resilient fungal infections.

Key Insights:

  • Identification of novel antifungal resistance mechanisms in dermatophytes is critical.
  • Understanding the epidemiology of resistant dermatophyte spread is essential for control.
  • Development of new diagnostic and therapeutic approaches is urgently required.

Outlook:

  • Further research into dermatophyte resistance is vital for effective treatment.
  • Clinical practice must adapt to address the challenge of antifungal drug resistance.
  • Global collaboration is necessary to contain and manage the spread of resistant infections.
Keywords:
DermatophyteDrug resistanceInfectionTerbinafine

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