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Updated: Jul 14, 2025

Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
HAT-Mediated Electrochemical C(sp2)-H Acylation of Quinolines with Alcohols
Yujie Liao1, Cong Jiang1, Congcong Qiang1
1School of Chemistry and Materials Science, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, China.
Abstract:
Herein, an electrochemical hydrogen atom transfer (HAT) strategy for C(sp2)-H formylation of electron-deficient quinolines and isoquinolines is described. The cheap methanol acts as a formyl source with a catalytic amount of N-hydroxyphthalimide (NHPI) as the hydrogen atom transfer (HAT) catalyst. The advantages of this reaction are transition-metal-catalyst- and chemical-oxidant-free conditions, and the protocol could also be applied to the direct C(sp2)-H acetylation or propionylation of quinolines.
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