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Brugada syndrome in infants (<12 months): A case report and literature review

Krishna Kishore Umapathi1, Veronica Godsey2, Hsieh Ting Chang3

  • 1Division of Pediatric Cardiology, Department of Pediatrics, Charleston Area Medical Center, Charleston, West Virginia, USA.

Pacing and Clinical Electrophysiology : PACE
|October 5, 2023
PubMed

Insights

Infantile Brugada syndrome (BrS) is rare and poorly understood. This case highlights a malignant BrS phenotype in an infant, emphasizing the need for further research into early-onset cardiac conditions.

Area of Science:

  • Cardiology
  • Pediatric Electrophysiology
  • Genetic Cardiology

Background:

  • Brugada syndrome (BrS) is typically diagnosed in adults and older children.
  • Infantile-onset BrS is rare and lacks comprehensive characterization.
  • Early diagnosis and management of BrS in infants remain challenging.

Purpose of the Study:

  • To report a case of malignant Brugada syndrome with onset in infancy.
  • To review existing literature on infantile-onset BrS.
  • To discuss unique features and clinical implications of BrS in this population.

Main Methods:

  • Case report of a 7-year-old male with infantile-onset Brugada syndrome.
  • Detailed clinical presentation including cardiac arrests due to ventricular tachycardia and fibrillation.
  • Comprehensive literature review of infantile-onset Brugada syndrome.

Main Results:

  • The patient presented at 8 months of age with a malignant BrS phenotype.
  • Multiple episodes of ventricular tachycardia and ventricular fibrillation led to cardiac arrests.
  • The patient ultimately succumbed to the condition.
  • Literature review identified limited but distinct characteristics of infantile BrS.

Conclusions:

  • Malignant Brugada syndrome can manifest in early infancy.
  • Infantile-onset BrS presents unique challenges in diagnosis and management.
  • Further research is crucial to understand and treat this rare pediatric cardiac condition.

Keywords:
Brugada syndromeSCN5Ainfantventricular fibrillation

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