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Related Experiment Videos

Oncogenes with potential nuclear function: myc, myb and fos.

R N Eisenman, C B Thompson

    Cancer Surveys
    |January 1, 1986
    PubMed
    Summary

    Nuclear oncogenes like c-myc, c-myb, and c-fos regulate cell proliferation and differentiation. Their expression patterns and effects vary, suggesting distinct roles in cell cycle control and development.

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    Area of Science:

    • Molecular Biology
    • Oncogenesis
    • Cellular Regulation

    Background:

    • Retroviral oncogenes (v-myc, v-myb, v-fos) and their cellular counterparts (c-myc, c-myb, c-fos) are predominantly nuclear proteins.
    • These 'nuclear oncogenes' are implicated in cellular proliferation and differentiation due to their oncogenic potential.

    Purpose of the Study:

    • To investigate the roles of c-myc, c-myb, and c-fos in cellular proliferation and differentiation.
    • To understand the expression patterns and regulatory mechanisms of these nuclear oncogenes.

    Main Methods:

    • Detailed studies on the expression of c-myc, c-myb, and c-fos in various cell types.
    • Analysis of RNA and protein products, including half-lives and phosphorylation.
    • Examination of nuclear localization and association of these proteins.

    Main Results:

    • All three proto-oncogenes are expressed during proliferation with short half-lives, suggesting regulatory roles.
    • c-myc and c-fos are induced during cell cycle entry; c-myb peaks during S phase preparation.
    • Expression patterns differ during differentiation: c-myc/c-myb cease, while c-fos can be induced.

    Conclusions:

    • Unregulated expression of myc, myb, and fos has distinct effects on differentiation.
    • Regulation occurs via post-transcriptional mechanisms (c-myc, c-myb) and transcriptional control (c-fos).
    • These nuclear oncogenes possess distinct regulatory functions in cellular proliferation and differentiation.

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