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Updated: May 23, 2026

Assessment of the Metabolic Profile of Primary Leukemia Cells

Published on: November 21, 2018

Rethinking the regulation of cellular metabolism.

¹Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. craig@mskcc.org

Cold Spring Harbor Symposia on Quantitative Biology

|March 21, 2012

Summary

This summary is machine-generated.

Cellular metabolism is not self-regulating; signal transduction events influence nutrient uptake and metabolic processes in metazoan cells. This challenges the long-held view of cell autonomy in metabolism.

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Area of Science:

Cell Biology
Biochemistry
Metabolic Regulation

Background:

Traditional biological models viewed cellular metabolism as a self-regulating, homeostatic process.
This perspective assumed metabolic control was independent of extracellular signals and cell-autonomous.
The link between signal transduction pathways and cellular energy-intensive processes was largely unexamined.

Purpose of the Study:

To investigate the connection between signal transduction and cellular metabolism.
To challenge the established paradigm of cell-autonomous nutrient uptake and metabolism.
To explore how external signals influence cellular energy processes.

Main Methods:

Review of existing evidence challenging cell-autonomous metabolism.
Analysis of signal transduction pathways influencing cellular processes.
Examination of nutrient uptake mechanisms in metazoan cells.

Main Results:

A significant body of evidence contradicts the notion of cell-autonomous metabolism.
Signal transduction events are linked to cellular processes like growth and division.
Metazoan cells' nutrient uptake and metabolism are influenced by external factors.

Conclusions:

Cellular metabolism is not solely a homeostatic, self-regulating process.
Signal transduction pathways play a crucial role in regulating cellular metabolism.
The traditional view of cell-autonomous metabolism requires re-evaluation based on new evidence.