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Peripheral Mechanism of Cancer-Induced Bone Pain.
Yachen Yang1, Wei Yang1, Ruofan Zhang1
1Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Institute of Acupuncture Research, Institutes of Integrative Medicine, Fudan University, Shanghai, 200032, China.
Neuroscience Bulletin
|October 5, 2023
Summary
Cancer-induced bone pain (CIBP) stems from bone tumors and metastasis. Understanding its peripheral mechanisms, including tumor microenvironment interactions, is crucial for developing effective pain relief strategies.
Area of Science:
- Oncology
- Pain Medicine
- Neuroscience
Background:
- Cancer-induced bone pain (CIBP) is a significant challenge in cancer care, often inadequately managed by current therapies.
- CIBP presents unique characteristics while sharing features with inflammatory and neuropathic pain states.
- Complete pain relief for CIBP remains elusive, highlighting the urgent need for novel therapeutic approaches.
Purpose of the Study:
- To review the peripheral mechanisms underlying the initiation of cancer-induced bone pain.
- To explore the role of the tumor microenvironment (TME) and associated cellular crosstalk in CIBP.
- To discuss current treatments and identify potential therapeutic targets for CIBP.
Main Methods:
- Literature review focusing on peripheral mechanisms of CIBP.
- Analysis of the interplay between nerve cells, cancer cells, and immune cells within the TME.
- Examination of changes in the bone tissue and dorsal root ganglion relevant to CIBP.
Main Results:
- The peripheral mechanism of CIBP involves bone tissue injury and alterations within the TME.
- Nerve-cancer and cancer-immunocyte crosstalk in the TME promotes tumor progression and CIBP.
- Specific molecular and cellular interactions in the TME are key drivers of CIBP.
Conclusions:
- Peripheral mechanisms, particularly TME-related crosstalk, are central to CIBP development.
- Targeting these peripheral pathways offers promising avenues for developing new analgesics.
- Further research into nerve-cancer and cancer-immune interactions is essential for effective CIBP management.
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