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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Elevated Intraocular Pressure Moderated Brain Morphometry in High-tension Glaucoma: a Structural MRI Study.

Liang Jing1, Tingqin Yan2, Jian Zhou3

  • 1Center of Radiation Therapy, Taian Tumor Hospital, Taian, China.

Clinical Neuroradiology
|October 5, 2023
PubMed
Summary

High-tension glaucoma (HTG) is linked to brain changes. Elevated intraocular pressure (IOP) in HTG patients correlated with reduced cortical thickness in specific brain regions, suggesting IOP impacts brain morphology.

Keywords:
Brain morphometryHigh-tension glaucomaIntraocular pressureStructural MRI

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Medical Imaging

Background:

  • High-tension glaucoma (HTG) is a prevalent form of primary open-angle glaucoma.
  • Elevated intraocular pressure (IOP) is a key characteristic of HTG.
  • The impact of elevated IOP on brain morphology in HTG patients requires further investigation.

Purpose of the Study:

  • To investigate the association between elevated intraocular pressure (IOP) and brain morphological alterations in patients with high-tension glaucoma (HTG).
  • To determine if brain morphometry in HTG patients is correlated with their mean IOP.
  • To analyze the moderating effect of IOP on the relationship between subject type (HTG vs. healthy controls) and brain morphometry.

Main Methods:

  • Acquisition of T1-weighted structural MRI images from 56 participants (36 HTG patients, 20 healthy controls).
  • Statistical analysis to test for correlations between mean IOP and brain morphometry in the HTG group.
  • Moderation analysis to assess interactions between subject type and IOP concerning cortical thickness.

Main Results:

  • Negative correlation observed between mean IOP and cortical thickness in several brain regions (left rostral middle frontal gyrus, left pars triangularis, right precentral gyrus, left postcentral gyrus, left superior temporal gyrus) in HTG patients.
  • Reduced cortical thickness in HTG patients compared to controls was found in four regions: left rostral middle frontal gyrus, left pars triangularis, left postcentral gyrus, and left superior temporal gyrus.
  • IOP significantly moderated the relationship between subject type and cortical thickness in the left rostral middle frontal gyrus, left pars triangularis, left postcentral gyrus, and left superior temporal gyrus.

Conclusions:

  • Elevated intraocular pressure in high-tension glaucoma may lead to significant brain morphometric alterations, including cortical thinning.
  • The identified brain regions showing altered morphology are crucial for cognitive and motor functions.
  • These findings highlight the importance of IOP regulation for preserving brain structure and function in HTG patients.