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Outcomes of patients with acute coronary syndrome according to COVID-19 vaccination status

Ranin Hilu1, Zahi Abu Ghosh2, David Leibowitz2

  • 1Cardiology Department, Meir Medical Center, Kfar-Saba and Sackler Faculty of Medicine, Tel-Aviv University.

Coronary Artery Disease
|October 6, 2023
PubMed

Insights

COVID-19 vaccination did not impact outcomes for patients experiencing acute coronary syndrome (ACS). This study supports the cardiovascular safety of COVID-19 mRNA vaccines in high-risk individuals.

Area of Science:

  • Cardiology
  • Vaccinology
  • Public Health

Background:

  • COVID-19 vaccination is linked to reduced acute coronary syndrome (ACS) risk.
  • Concerns exist regarding potential cardiovascular complications post-vaccination.
  • The impact of vaccination status on ACS patient treatment and outcomes requires investigation.

Purpose of the Study:

  • To evaluate the effect of COVID-19 vaccination status on the management and prognosis of patients with acute coronary syndrome (ACS).

Main Methods:

  • Retrospective analysis of the 2021 Acute Coronary Syndrome Israeli Survey.
  • Stratification of 1261 ACS patients into vaccinated (≥2 doses within 1 week of hospitalization) and unvaccinated groups.
  • Primary endpoint: 1-year all-cause mortality; secondary endpoint: 30-day Major Adverse Cardiovascular Events (MACE).

Main Results:

  • 990 (78.5%) patients were vaccinated; vaccinated individuals were older and less likely to smoke.
  • No significant differences in reperfusion rates or guideline-based medical therapy between groups.
  • 1-year mortality (3.8% vs 5.2%, P=0.42) and 30-day MACE (9.5% vs 11.5%, P=0.39) showed no significant difference, even after adjusting for confounders.

Conclusions:

  • COVID-19 vaccination status was not associated with adverse outcomes in ACS patients.
  • Findings support the cardiovascular safety of COVID-19 mRNA vaccines, particularly for individuals at high cardiovascular risk.
Abstract

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