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Arf6 as a therapeutic target: Structure, mechanism, and inhibitors

Dejuan Sun1, Yuanyuan Guo1, Piyu Tang1

  • 1Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.

Acta Pharmaceutica Sinica. B
|October 6, 2023
PubMed

Insights

ADP-ribosylation factor 6 (Arf6) is crucial for cancer cell growth and invasion. Understanding Arf6 function and its inhibitors offers potential for new cancer therapies and overcoming drug resistance.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • ADP-ribosylation factor 6 (Arf6), a Ras superfamily G-protein, regulates key cellular processes like exocytosis, endocytosis, and actin remodeling.
  • Arf6 activity is implicated in promoting cancer cell motility and invasion, making it a significant factor in cancer progression.
  • Aberrant Arf6 activation presents a potential target for novel cancer therapeutics.

Purpose of the Study:

  • To comprehensively review the multifaceted functions of Arf6 in the context of cancer.
  • To explore Arf6's role in cancer cell growth, survival, and drug resistance.
  • To identify potential therapeutic strategies targeting Arf6 for cancer treatment.

Main Methods:

  • Literature review summarizing existing research on Arf6.
  • Analysis of Arf6 guanine nucleotide exchange factors (GEFs) and protein structure.
  • Compilation of known Arf6 inhibitors and their mechanisms of action.

Main Results:

  • Detailed summary of Arf6's structural features and its involvement in cancer.
  • Identification of Arf6 as a key regulator of cancer cell motility and invasion.
  • Discussion of Arf6's contribution to cancer drug resistance.

Conclusions:

  • A thorough understanding of Arf6's mechanism in cancer is essential for developing effective therapies.
  • Arf6 structural insights may guide the development of novel protein-protein interaction inhibitors.
  • Arf6 represents a promising target for future cancer therapy, including overcoming drug resistance.
Keywords:
Arf6Drug resistanceInhibitorsMechanismStructure

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