Respiratory Distress Caused by Neoplastic Upper Respiratory Tract Obstructions in 2 Pet Rats (Rattus norvegicus...

Area of Science:

• Veterinary Medicine
• Rodent Pathology
• Comparative Oncology

Background:

• Respiratory disease is a common concern for pet rat owners.
• While chronic respiratory disease complex is well-documented, upper airway obstruction is rarely reported.

Observation:

• Two pet rats presented with progressive respiratory signs unresponsive to standard treatments.
• Diagnostic imaging revealed tracheal narrowing and masses, with one case showing laryngeal obstruction.

Findings:

• Necropsy identified squamous cell carcinoma obstructing the larynx in one rat.
• The second rat had an intra-luminal tracheal mass, likely lymphoma or plasma cell tumor.
• Both cases experienced severe respiratory compromise leading to cardiopulmonary arrest or euthanasia.

Implications:

• This report underscores the importance of considering non-infectious causes, particularly neoplastic processes, in rat respiratory disease.
• Diagnostic imaging is crucial for identifying upper airway obstructions.
• Early recognition and further investigation beyond empiric treatment are vital for improving outcomes in pet rats with severe respiratory distress.